Evidence map›Paper›PMID 41438109›Full record

SynthesisPeerJ2025

Fructose consumption and metabolic hypertension in rats: a systematic review and meta-analysis.

Arya Vs, Arunkumar Subramanian, Kavitha Rajendran, Tamilanban Thamaraikani, Vinoth Kumarasamy, Mok Shiueh Lian, Rusli Bin Nordin, Mahendran Sekar, Vetriselvan Subramaniyan, Manasa Karnam and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arya Vs *Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India.
Arunkumar Subramanian *Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India.
Kavitha RajendranDepartment of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India.
Tamilanban ThamaraikaniDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India.
Vinoth KumarasamyDepartment of Parasitology & Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Kuala Lumpur, Malaysia.
Mok Shiueh LianDepartment of Pharmacology, Faculty of Medicine, MAHSA University, Bandar Saujana Putra, Selangor, Malaysia.
Rusli Bin NordinDepartment of Pharmacology, Faculty of Medicine, MAHSA University, Bandar Saujana Putra, Selangor, Malaysia.
Mahendran SekarSchool of Pharmacy, Monash University, Bandar Sunway, Subang Jaya, Selangor, Malaysia.
Vetriselvan SubramaniyanDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India.
Manasa KarnamDepartment of Pharmacology, MNR College of Pharmacy, Sangareddy, Telangana, India.
Steni SackiriyasPhysical Therapy Program, Health Science Center, University of Wisconsin-La Crosse, WI, United States of America.
Ling Shing WongFaculty of Health and Life Sciences, INTI International University, Nilai, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypertension is a growing cardiovascular risk, increasingly linked to dietary changes. This meta-analysis examines the impact of dietary fructose on hypertension by evaluating the mean difference in systolic blood pressure (SBP) in rats, considering fructose intake levels (10-30% in solution; 60-75% in diet) and exposure duration (<8 weeks, 8 weeks and >8 weeks). Materials and Methods: A comprehensive search across Cochrane, Web of Science, Scopus and Ovid (MEDLINE, Embase, AMED) databases identified relevant reports published until December 2022. The meta-analysis, conducted using Review Manager 5.4 software, included a total of 24 studies, with quantitative data analysed through a random-effects model. Results: Fructose treatment significantly raised SBP in rats by 31.05 mmHg (95% CI [24.36-37.74], Conclusion: Animal studies suggest that fructose intake may contribute to elevated SBP, potentially increasing the risk of hypertension. While trends were observed across various doses and exposure durations, not all findings reached statistical significance. These observations highlight the importance of further research into the long-term effects of fructose on human blood pressure and their relevance to dietary guidelines and public health policies.

Indexed as

FructoseHypertensionAnimalsBlood PressureDisease Models, AnimalRatsFructoseBlood pressureCardiovascular disordersHigh fructose dietMetabolic hypertensionPublic health

Identifiers

PMID41438109
PMCPMC12721104

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.