Evidence map›Paper›PMID 41438618›Full record

ArticleGenetics research2025

Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases.

Fu Sun, Haochang Li, Bin Gong, Shirong Hui, Ran He, Meijie Yu, Yihao Li, Sheng Yang, Peng Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fu SunThe People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, 212300, China.
Haochang LiDepartment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 211166, China, njmu.edu.cn.
Bin GongThe People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, 212300, China.
Shirong HuiDepartment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 211166, China, njmu.edu.cn.
Ran HeDepartment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 211166, China, njmu.edu.cn.
Meijie YuDepartment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 211166, China, njmu.edu.cn.
Yihao LiDepartment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 211166, China, njmu.edu.cn.
Sheng YangDepartment of Biostatistics, Center for Global Health, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 211166, China, njmu.edu.cn.
Peng HuangDepartment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 211166, China, njmu.edu.cn.ORCID 0000-0002-0146-921X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies on the causal relationship or shared genetic basis between major depression disorder (MDD) and gastrointestinal (GI) diseases covered either a limited range and not comprehensive enough. Methods: We used linkage disequilibrium score regression (LDSC) to estimate the heritability for nine traits and the genetic correlation ( Results: For the heritability, heritability of all nine traits was significant. For genetic correlation, six GI diseases showed significant correlations with MDD. For the result of MR, we revealed the causal relationship between MDD and acute appendicitis (OR = 1.09), irritable bowel syndrome (IBS) (OR = 1.14), and ulcer of esophagus (OR = 1.24). Additionally, we found no significant overlapping tissues after S-LDSC. Finally, we defined three shared genes: Conclusions: Our findings provided the evidence of genetic association, causal relationship, and shared pleiotropic genes between MDD and GI diseases especially acute appendicitis, offering new insights into our understanding of their shared genetic basis.

Indexed as

Gastrointestinal DiseasesGenetic Predisposition to DiseaseMajor Depressive DisorderGenetic PleiotropyGenome-Wide Association StudyHumansLinkage DisequilibriumMendelian Randomization AnalysisPolymorphism, Single Nucleotidecausal relationshipgastrointestinal diseasesmajor depression disordershared genetic basis

Identifiers

PMID41438618
PMCPMC12721742

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.