Evidence map›Paper›PMID 41438692›Full record

ArticleBiochemistry and biophysics reports2026

Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice.

Harumi Hisaki, Takao Susa, Noriyuki Okudaira, Miho Akimoto, Masayoshi Iizuka, Junko Matsuda, Shunya Uchida, Hiroko Okinaga, Tomoki Okazaki, Mimi Tamamori-Adachi

Abstract read
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In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Harumi HisakiDepartment of Biochemistry, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Takao SusaDepartment of Biochemistry, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Noriyuki OkudairaDepartment of Biochemistry, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Miho AkimotoDepartment of Biochemistry, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Masayoshi IizukaDepartment of Biochemistry, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Junko MatsudaDepartment of Pathophysiology and Metabolism, Kawasaki Medical School, Okayama, Japan.
Shunya UchidaTeikyo Heisei University, Toshima, Tokyo, Japan.
Hiroko OkinagaDepartment of Internal Medicine, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Tomoki OkazakiDepartment of Biochemistry, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Mimi Tamamori-AdachiDepartment of Biochemistry, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prosaposin (PSAP), a precursor of saposins, is essential for lysosomal hydrolysis of sphingolipids. It binds with progranulin (PGRN) and transports from the Golgi to lysosomes, where it is processed into saposins. PSAP is also secreted and functions on various cells, including neurons. We found that PSAP is highly expressed in the subfornical organ (SFO), a thirst center, in SAP-D-deficient (SAP-D

Indexed as

MicrogliaPGRNPrimary polydipsiaPSAPSaposin-DSubfornical organ

Identifiers

PMID41438692
PMCPMC12720004

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.