ArticleBlood vessels, thrombosis & hemostasis2026
High incidence of thrombin generation resistance to thrombomodulin in patients with unprovoked venous thromboembolism.
Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Poorly controlled thrombin generation (TG) can induce venous thromboembolism (VTE). Assessing the global coagulation potential may help to characterize the risk of VTE. TG assay (TGA) quantifying the endogenous thrombin potential (ETP) and its inhibition after adding purified thrombomodulin (TM) allows certain thrombotic phenotypes to be recognized. We tested the TM-induced ETP variation in 989 uncoagulated patients with their first unprovoked VTE and 200 controls using an automated TGA and commercially available reagents. We found evidence of ETP resistance to TM, defined at the fifth percentile value found in controls, in 406 patients (41.1%,
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