ArticleFrontiers in immunology2025
SCPEP1
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Plasma SH Concentrations and Mortality in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal interstitial lung disease marked by progressive extracellular matrix accumulation and irreversible lung architecture remodeling. Oxidative stress (OS) plays a crucial role in IPF pathogenesis, yet its role across distinct cellular compartments and tissue microenvironments remains incompletely characterized. Methods: We integrated single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (stRNA-seq), and bulk RNA-seq datasets to comprehensively characterize oxidative stress activity across cellular and tissue scales in IPF lungs. Oxidative stress scores were calculated using multiple enrichment algorithms, and machine learning models (LASSO, Random Forest, Boruta, Bayesian, LVQ, Treebag) were applied to identify robust OS-related diagnostic biomarkers. Expression patterns were validated in public datasets and a bleomycin-induced C57BL/6 mouse model. Cell-cell communication and gene regulatory pathways were further explored using CellChat and pseudotime trajectory analysis. Results: Oxidative stress activity was significantly elevated in IPF lung tissue and specifically enriched in basal cells. Among 71 candidate OS-related genes, SCPEP1 emerged as the most robust biomarker, consistently upregulated across multiple datasets and experimental validation, with an AUC of 0.857 in the training cohort. SCPEP1 expression was spatially confined to airway-adjacent regions and highly specific to basal cells. SCPEP1 Conclusion: Our multi-omics integration revealed SCPEP1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.