ArticlePulmonary circulation2025
Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis.
Claudia Mickael, Jane C Kabwe, Dara Fonseca Balladares, Annika S Bai, Kevin Nolan, Michael H Lee, Rahul Kumar, Joan F Hilton, Joseph Phiri, Taonga Musonda and 8 more
Abstract readLetter
In one paragraphArticle in Pulmonary circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Claudia MickaelCardiovascular Pulmonary Laboratory University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Dara Fonseca BalladaresDivision of Pulmonary and Critical Care Medicine University of California San Francisco San Francisco California USA.
Annika S BaiDivision of Pulmonary and Critical Care Medicine University of California San Francisco San Francisco California USA.
Kevin NolanDivision of Pulmonary and Critical Care Medicine University of California San Francisco San Francisco California USA.
Rahul KumarDivision of Pulmonary and Critical Care Medicine University of California San Francisco San Francisco California USA.
Joan F HiltonDepartment of Epidemiology and Biostatistics University of California San Francisco San Francisco California USA.
Joseph PhiriDepartment of Anesthesia National Heart Hospital Lusaka Lusaka Province Zambia.
Taonga MusondaDepartment of Medicine University Teaching Hospital Lusaka Lusaka Province Zambia.
Katie TuscanDivision of Pulmonary Sciences and Critical Care Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Linda SandersDivision of Pulmonary Sciences and Critical Care Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Kurt R StenmarkCardiovascular Pulmonary Laboratory University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Paul W BuehlerCenter for Blood Oxygen Transport and Hemostasis, Departments of Pediatrics and Pathology University of Maryland Baltimore School of Medicine Baltimore Maryland USA.
Edford SinkalaDepartment of Medicine University Teaching Hospital Lusaka Lusaka Province Zambia.
David C IrwinCardiovascular Pulmonary Laboratory University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Sula MazimbaAdvanced Heart Failure and Transplant Cardiology, AdventHealth Orlando Florida USA.
Brian B GrahamMorningstar Clinic Lusaka Lusaka Province Zambia.
Funding
Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI TUDER, RUBIN M. · 2020 to 2024
$14.1MInvestigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1MNovel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary HypertensionK01HL161024 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Claudia Silva Mickael · 2022 to 2026
$661kScreening for schistosomiasis-associated pulmonary arterial hypertensionR21AI171968 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRAHAM, BRIAN BARKLEY, HILTON, JOAN F · 2023 to 2024
$465kNHLBI NIH HHS K01 HL161024NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R01 HL135872NIAID NIH HHS R21 AI171968
6 · The paper itselfAbstract
Schistosomiasis and sickle cell disease (SCD) both cause pulmonary hypertension (PH). We identified a subject with sickle cell trait and hepatosplenic schistosomiasis, who on right heart catheterization had PH, but due to high cardiac output. In a pre-clinical model, we found SCD mice were protected from developing schistosomiasis-induced PH.
Indexed as
clinical researchco‐infectionmouse modelsTGF‐beta
Identifiers
PMID41438844
PMCPMC12720281
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390