Design and evaluation of ionically crosslinked multifunctional ELP-SA composite hydrogels for 3D cell culture.

Yiying Chen, Yangmin Wang, Yuxi Li, Xingyang Chen, Wenyun Zheng, Tianwen Wang, Hao Jia, Xingyuan Ma

Abstract read

In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiying ChenSchool of Biotechnology and State Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai 200237, China.

Yangmin WangSchool of Biotechnology and State Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai 200237, China.

Yuxi LiSchool of Biotechnology and State Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai 200237, China.

Xingyang ChenSchool of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China.

Wenyun ZhengSchool of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China.

Tianwen WangCollege of Biological and Food Engineering Anhui Polytechnic University, Wuhu 241000, China.

Hao JiaShanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry & Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-1856-6013

Xingyuan MaSchool of Biotechnology and State Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai 200237, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogels are 3D crosslinked polymeric networks that can absorb and retain substantial quantities of water or biological fluids. Their soft, hydrated nature and adjustable properties render them highly suitable for a range of biomedical applications, such as drug delivery, tissue engineering and wound healing, by emulating the extracellular matrix. To overcome the limitations associated with the mechanical properties and biological functions of conventional elastin-like polypeptide (ELP) and sodium alginate (SA) hydrogels, a novel ion-responsive two-component ELP-SA hydrogel was developed. ELP variants with functional modules (ELPK/ELPR/ELPS/ELPL) were engineered through genetic techniques and purified to a high degree of purity (>95%) using high-salt-reversible phase-change technology. The release of Ca

Indexed as

3D cell culturecomposite hydrogelelastin-like polypeptidesodium alginate

Identifiers

PMID41439199

DOI10.1093/rb/rbaf120

PMCPMC12721863

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.