ArticleOphthalmology science2026
Perilesional Fundus Autofluorescence Patterns Are Not Static: Longitudinal Transitions in Geographic Atrophy and Association with Disease Progression.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Incomplete Retinal Pigment Epithelium and Outer Retinal Atrophy Characterized Using Fundus Autofluorescence: An 18-Month Post Hoc Analysis of GATHER2.Investigative ophthalmology & visual science · 2026Trial
- Re: "Antropoli A et al. Perilesional fundus autofluorescence patterns are not static: longitudinal transitions in geographic atrophy and association with disease progression".Ophthalmology science · 2026Article
- Reply.Ophthalmology science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate cross-sectional characteristics and longitudinal changes in perilesional fundus autofluorescence (FAF) patterns in geographic atrophy (GA). Study Design: Retrospective cohort study. Participants: One hundred forty-three eyes from 99 patients (70 females) with foveal-sparing GA at baseline, of which 106 eyes from 76 patients were eligible for longitudinal analyses. Methods: Best-corrected visual acuity, FAF, and OCT findings were collected at all visits. Baseline FAF patterns were determined using a 5-item classification, with tracking of longitudinal changes. Changes in GA growth rate following pattern transitions were investigated through linear mixed models. Main Outcome Measures: Frequency and timing of perilesional FAF pattern transitions, and their association with GA growth rate. Results: Of the 106 eyes with follow-up, 23 (22%) showed a change in perilesional FAF pattern after a median of 3 years (interquartile range: 1.74-4.10). Square root GA growth rate was 0.40 mm/year (95% confidence interval [CI]: 0.34-0.46; Conclusions: Perilesional FAF pattern transitions occur in a subset of GA eyes and are marked by slower progression, underscoring their potential relevance for disease monitoring and clinical trial design. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.