ArticleeLife2025
Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Macrophage regulation of hypothalamic-pituitary-adrenal and gonadal axis homeostasis and hormonal output.Biomedical journal · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin-aldosterone system, situated in the adrenal glands, kidneys, and lungs. Here, we reveal that the class A scavenger receptor MARCO, expressed on alveolar macrophages, negatively regulates aldosterone production and suppresses angiotensin-converting enzyme (Ace) expression in the lungs of male mice. Collectively, our findings suggest alveolar macrophages as additional players in the renin-angiotensin-aldosterone system and introduce a novel example of interplay between the immune and endocrine systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.