Evidence map›Paper›PMID 41439999›Full record

ArticleCells2025

KRT6A and KRT17 Mark Distinct Stem Cell Populations in the Adult Palpebral Conjunctiva and Meibomian Gland.

Xuming Zhu, Mingang Xu, David M Owens, Sarah E Millar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Xuming ZhuBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-1148-4162
Mingang XuBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
David M OwensDepartment of Dermatology, Columbia University, New York, NY 10032, USA.
Sarah E MillarBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-8792-6890

Funding

Skin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2M
WNT signals in skin and hair development and hair growthR37AR047709 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MILLAR, SARAH E. · 2012 to 2021
$3.6M
Molecular mechanisms controlling skin heterogeneityR01AR081322 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sarah E. Millar · 2022 to 2026
$3.0M
Investigating the role for Utrophin in age-related decline of the Merkel lineageR01AG073874 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWENS, DAVID MICHAEL · 2021 to 2025
$2.0M
KLF-mediated coordination of signaling and epigenetic mechanisms in the skinR01AR076428 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MILLAR, SARAH E. · 2020 to 2024
$1.8M
Epigenetic regulation of the Meibomian gland in homeostasis and agingR01EY036095 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sarah E. Millar · 2025 to 2026
$1.4M
NEI NIH HHS R01 EY036095NIAMS NIH HHS P30 AR079200NIAMS NIH HHS R01 AR076428NIAMS NIH HHS R01 AR081322NIAMS NIH HHS R37 AR047709NIAMS NIH HHS R37AR047709, RO1AR081322, R01AR076428, P30AR079200NIA NIH HHS R01 AG073874
6 · The paper itself

Abstract

purposeThis study aims to investigate whether two stress keratins, KRT6A or KRT17, label self-renewing stem cells (SCs) in adult mouse Meibomian gland (MG), the palpebral conjunctiva (PC) homeostasis, and to explore the mechanisms regulating their expression.

methodsKRT6A and KRT17 expression in adult mouse MG and PC were examined by single-nucleus RNA sequencing and immunofluorescence (IF). Lineage-tracing experiments were performed using

resultsKRT6A and KRT17 are primarily expressed in the MG central duct and ductules. KRT6A also shows robust expression in PC. Lineage tracing indicated that

conclusions

Indexed as

ConjunctivaKeratin-17Keratin-6Meibomian GlandsStem CellsAnimalsFemaleHistone Deacetylase 3HumansKeratinsMaleMiceMice, Inbred C57BLRegenerationSignal TransductionHistone Deacetylase 3Keratin-17Keratin-6KeratinsKRT17 protein, humanKrt17 protein, mouseKRT6A protein, humanKrt6a protein, mouseconjunctivaGLI2HDAC3KLF4KRT17KRT6Ameibomian gland

Identifiers

PMID41439999
PMCPMC12732064

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.