Evidence map›Paper›PMID 41440017›Full record

SynthesisCells2025

Cellular and Molecular Mechanisms of Non-Invasive Brain Stimulation Techniques: A Systematic Review on the Implications for the Treatment of Neurological Disorders.

Valerio Sveva, Marco Mancuso, Alessandro Cruciani, Elias Paolo Casula, Giorgio Leodori, Silvia Antonella Selvaggi, Matteo Bologna, Vincenzo Di Lazzaro, Anna Latorre, Lorenzo Rocchi

Abstract readSystematic Review
In one paragraph

Synthesis in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Focused and unfocused transcranial ultrasound stimulation in Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valerio SvevaDepartment of Human Neuroscience, University of Rome "Sapienza", Viale dell'Università 30, 00185 Rome, Italy.ORCID 0000-0002-3757-8186
Marco MancusoDepartment of Human Neuroscience, University of Rome "Sapienza", Viale dell'Università 30, 00185 Rome, Italy.ORCID 0000-0002-4485-2200
Alessandro CrucianiUnit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0002-2631-4185
Elias Paolo CasulaDepartment of System Medicine, University of Tor Vergata, Via Cracovia 50, 00133 Rome, Italy.
Giorgio LeodoriDepartment of Human Neuroscience, University of Rome "Sapienza", Viale dell'Università 30, 00185 Rome, Italy.ORCID 0000-0002-6631-6740
Silvia Antonella SelvaggiUnit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Matteo BolognaDepartment of Human Neuroscience, University of Rome "Sapienza", Viale dell'Università 30, 00185 Rome, Italy.
Vincenzo Di LazzaroUnit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0002-9113-5925
Anna LatorreDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1E 6BT, UK.ORCID 0000-0001-7103-5209
Lorenzo RocchiDepartment of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria di Monserrato, Blocco I S.S. 554 bivio per Sestu, Monserrato, 09042 Cagliari, Italy.ORCID 0000-0003-3979-156X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive brain stimulation (NIBS) techniques-including repetitive transcranial magnetic stimulation (rTMS), theta-burst stimulation (TBS), paired associative stimulation (PAS), transcranial direct current stimulation (tDCS), and transcranial alternating current stimulation (tACS)-have emerged as valuable tools for modulating neural activity and promoting plasticity. Traditionally, their effects have been interpreted within a binary framework of long-term potentiation (LTP)-like and long-term depression (LTD)-like plasticity, largely inferred from changes in motor evoked potentials (MEPs). However, existing models do not fully capture the complexity of the biological processes engaged by these techniques and despite extensive clinical application, the cellular and molecular mechanisms underlying NIBS remain only partially understood. This systematic review, conducted in accordance with the PRISMA 2020 guidelines, synthesizes evidence from in vivo, in vitro, and ex vivo studies to delineate how NIBS influences neurotransmission through intracellular signaling, gene expression, and protein synthesis at the cellular level. Emphasis is placed on the roles of classical synaptic models, grounded in Ca

Indexed as

BrainNervous System DiseasesTranscranial Direct Current StimulationTranscranial Magnetic StimulationAnimalsHumansNeuronal Plasticitycellular mechanismgene expressionLTD-like plasticityLTP-likemolecular mechanismPASrTMStACSTBStDCS

Identifiers

PMID41440017
PMCPMC12732073

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.