Evidence map›Paper›PMID 41440022›Full record

ArticleCells2025

B Cells Can Trigger the T-Cell-Mediated Autoimmune Response Against Melanocytes in Psoriasis.

Mengwen He, Melissa Bernhardt, Akiko Arakawa, Song-Min Kim, Sigrid Vollmer, Burkard Summer, Yukiyasu Arakawa, Tatsushi Ishimoto, Andreas Schlosser, Jörg Christoph Prinz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengwen HeDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.ORCID 0000-0002-1891-6506
Melissa BernhardtRudolf Virchow Center, Center for Integrative and Translational Bioimaging, University Würzburg, D-97078 Würzburg, Germany.ORCID 0009-0004-2078-1454
Akiko ArakawaDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.ORCID 0000-0002-6679-3029
Song-Min KimDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.
Sigrid VollmerDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.
Burkard SummerDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.ORCID 0000-0002-8136-7335
Yukiyasu ArakawaDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.ORCID 0000-0003-4249-6393
Tatsushi IshimotoDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.ORCID 0000-0002-0105-572X
Andreas SchlosserRudolf Virchow Center, Center for Integrative and Translational Bioimaging, University Würzburg, D-97078 Würzburg, Germany.ORCID 0000-0003-0612-9932
Jörg Christoph PrinzDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany.ORCID 0000-0002-8857-5495

Funding

German Research Foundation PR 241/5-1 and 5-2Japanese Dermatological Association Grant-In-Aid for Study Abroad TI1Japan Society for the Promotion of Science 21K16234LMU-China Scholarship Council Program Scholarship No. 201706160167
6 · The paper itself

Abstract

Psoriasis vulgaris is a T-cell-mediated skin disease that may involve an autoimmune response against melanocytes. It develops through still unexplained pathomechanisms. Streptococcal tonsillopharyngitis is a major trigger of psoriasis onset and relapses.

Indexed as

AutoimmunityB-LymphocytesMelanocytesPsoriasisT-LymphocytesAdultCD8-Positive T-LymphocytesFemaleHLA-C AntigensHumansMaleHLA-C Antigensautoimmune diseaseB-cell immunopeptidomecrossreactive CD8+ T cellsHLA-C*06:02melanocytespsoriasis triggerPsoriasis vulgarisstreptococcal tonsillopharyngitis

Identifiers

PMID41440022
PMCPMC12732238

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.