Evidence map›Paper›PMID 41440141›Full record

ReviewBrain sciences2025

Pathways, Mechanisms, and Therapeutic Strategies of Neurotoxicity Induced by Micro- and Nanoplastics.

Min Yan, Yanfeng Chen, Ying Tao, Hui Wang, Xuewen Tian, Xiuxiu Wang

Abstract readReview
In one paragraph

Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min YanAcademy of Sports Sciences, Shandong Sport University, Jinan 250102, China.
Yanfeng ChenAcademy of Sports Sciences, Shandong Sport University, Jinan 250102, China.
Ying TaoAcademy of Sports Sciences, Shandong Sport University, Jinan 250102, China.
Hui WangAcademy of Sports Sciences, Shandong Sport University, Jinan 250102, China.
Xuewen TianAcademy of Sports Sciences, Shandong Sport University, Jinan 250102, China.
Xiuxiu WangAcademy of Sports Sciences, Shandong Sport University, Jinan 250102, China.

Funding

Scientific Research Startup Fund of Shandong Sport University 2390007
6 · The paper itself

Abstract

Plastic pollution now represents a global environmental crisis, as micro- and nanoplastics (MNPs) infiltrate organisms via multiple routes such as the digestive system and respiratory system, ultimately accumulating in tissues and endangering human health. The central nervous system exhibits particular vulnerability to MNPs toxicity, which can trigger neurotoxic effects and disrupt brain function, potentially contributing to neurological disorders. Understanding the precise mechanisms and biological pathways underlying MNP-induced neurotoxicity has therefore emerged as a critical step toward identifying therapeutic targets. This review synthesizes current knowledge on MNPs' entry routes into the brain, examines proposed neurotoxic mechanisms, and evaluates existing and prospective treatment approaches. These insights may inform both the risk assessment of MNPs exposure and the development of targeted interventions for neurological protection.

Indexed as

central nervous systemenvironmental pollutionmicroplasticsnanoplasticsneurotoxicitytherapeutic interventions

Identifiers

PMID41440141
PMCPMC12730739

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.