Article in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Tania V López-PérezLaboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.
Rogelio F Jiménez-OrtegaServicio de Medicina Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra (INRLGII), Mexico City 14389, Mexico.
Armando Cruz-RangelLaboratorio de Estructura de Proteínas, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0002-0113-0312
Diana I Aparicio-BautistaLaboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0003-0036-7227
Juan C Fernández-LópezDepartamento de Genómica Computacional, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0003-3680-4193
Adriana Becerra-CerveraLaboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.
Juan P Reyes-GrajedaLaboratorio de Estructura de Proteínas, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0001-6498-3286
Jorge SalmerónCentro de Investigación en Políticas, Población y Salud (CIPPS), Facultad de Medicina-Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Alberto Hidalgo-BravoServicio de Medicina Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra (INRLGII), Mexico City 14389, Mexico.ORCID 0000-0003-2506-8784
Berenice Rivera-ParedezCentro de Investigación en Políticas, Población y Salud (CIPPS), Facultad de Medicina-Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0002-9845-024X
Rafael Velázquez-CruzLaboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0003-4515-0777
Funding
Consejo Nacional de Ciencia y Tecnología 262233Consejo Nacional de Ciencia y Tecnología 26267 MConsejo Nacional de Ciencia y Tecnología 7876Consejo Nacional de Ciencia y Tecnología 87783Consejo Nacional de Ciencia y Tecnología CB-2013-01-221628Consejo Nacional de Ciencia y Tecnología CF2019 -102962Consejo Nacional de Ciencia y Tecnología SALUD-2010-01-139796Consejo Nacional de Ciencia y Tecnología SALUD-2011-01-161930Instituto Nacional de Medicina Genómica 266-17/2016/I
6 · The paper itself
Abstract
BACKGROUND/
objectivesSerum calcium concentrations have been associated with bone mineral density (BMD), but results seem to depend on sex. Genetic variants in the Ryanodine Receptor1 (
methodsSerum samples from 966 participants were obtained from the third measurement of the Health Workers Cohort Study (HWCS) 2017-2019, conducted by the Mexican Social Security Institute (IMSS). All participants included in this study were of Mexican Mestizo origin and had data on BMD. We measured ionized calcium and genotyped the genetic variants rs2288888 (g.38455542G>A) and rs11083462 (g.38469040C>T) of the
resultsOur results show that elevated serum calcium concentrations in females are associated with lower BMD at the hip and femoral neck. In contrast, higher calcium concentrations in males were associated with greater total hip BMD. In our study, the variants rs2288888 and rs11083462 were associated with higher serum calcium concentrations (under-adjusted and unadjusted data) in males but not females.
conclusionsSerum calcium levels are associated with BMD, depending on sex. The
Indexed as
Bone DensityCalciumRyanodine Receptor Calcium Release ChannelAdultAgedCross-Sectional StudiesFemaleGenotypeHumansMaleMexicoMiddle AgedOsteoporosisPolymorphism, Single NucleotideCalciumRyanodine Receptor Calcium Release ChannelRYR1 protein, humanbone mineral densitycalcium channelsRyanodine Receptor1serum calciumsynonymous variants
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in the · full record | Socratic