Evidence map›Paper›PMID 41440947›Full record

ArticleJournal of personalized medicine2025

Small Extracellular Vesicles Secreted by Cisplatin-Resistant Neuroblastoma Cells Increase Lactate Secretion and Alter Metabolic Pathways in Primary Human Umbilical Vein Endothelial Cells (HUVECs).

Thomas Frawley, Lin Ma, Muhammad Zainul Arifin, Dan Wu, Alysia Scott, Brenton Cavanagh, Donal F O'Shea, Vadim Zhernovkov, Mi Liu, Marco P Monopoli and 1 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thomas FrawleyCancer Bioengineering Group, Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.
Lin MaCancer Bioengineering Group, Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.
Muhammad Zainul ArifinSystems Biology Ireland, School of Medicine, University College Dublin, Temple Street, D04 C1P1 Dublin, Ireland.
Dan WuDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0002-5316-3706
Alysia ScottCancer Bioengineering Group, Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0002-7548-405X
Brenton CavanaghCellular and Molecular Imaging Core, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.ORCID 0000-0002-1582-5756
Donal F O'SheaDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.
Vadim ZhernovkovSystems Biology Ireland, School of Medicine, University College Dublin, Temple Street, D04 C1P1 Dublin, Ireland.ORCID 0000-0001-8903-1142
Mi LiuKunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, China.ORCID 0000-0002-5185-5872
Marco P MonopoliDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0002-2035-6894
Olga PiskarevaCancer Bioengineering Group, Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0003-4466-0441

Funding

AMBER Research Centres Phase 2 12/RC/2278_P2Irish Research Council - National Children's Research Centre EPSPG/2017/298National Children's Research Centre Project grant (A/17/2)RCSI - Soochow University StAR International PhD Programme n/aRCSI Strategic Academic Recruitment (StAR) Programme n/aScience Foundation Ireland 18/RI/5723
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cisplatin resistanceexosomal biomarkersextracellular vesiclesGene Set Enrichment Analysis (GSEA)liquid biopsiesmetabolismneuroblastomaproteomics

Identifiers

PMID41440947
PMCPMC12734324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.