ArticleMetabolites2025
Evaluation of Genome-Scale Model Reconstruction Strategies for
Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectivesGenome-scale metabolic models (GSM) are key tools for predicting microbial physiology, yet species within the genus
methodsDraft GSM models were generated from the
resultsAmong the five reconstructions, the KBase-derived draft demonstrated the highest quality and production potential for metabolites characteristic of heterofermentative fermentation. During manual curation of this model, reaction directions in central carbon metabolism and amino acid pathways were corrected. Analysis further identified an alternative NADH-regenerating glucose shunt via D-gluconate, supported by omics data and enzyme promiscuity considerations. Incorporation of this pathway resolved the redox imbalance and allowed the model to reproduce metabolic exchange profiles characteristic of obligate heterofermenters.
conclusionsWe developed the first manually curated genome-scale model of
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Registered trials
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