ReviewDiscover mental health2025
How three different theories of depression converge at inflammation.
Review in Discover mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three main theories of depression have been developed: the monoamine, plasticity and inflammation theories. While each theory has been bolstered by decades of excellent scientific evidence, individually each idea falls short for developing universally effective treatments for depression. In this perspective, we present the history and development of each theory and discuss the therapies that follow each hypothesis. We provide a unique perspective by highlighting the historical evolution, clinical implications, and the nexus between the three hypotheses. We emphasise how the theories are mutually inclusive and influence one another and are smaller parts of a larger puzzle. We suggest that future therapies should involve all three: ze: monoamines, plasticity and inflammation.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.