ArticleEuropean journal of applied physiology2026
Whole-body periodic acceleration: a new countermeasure against bone loss induced by long-term hindlimb unloading.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Common and Divergent Physiological Responses to Hypoxia and Heat.Sports medicine (Auckland, N.Z.) · 2026Review
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14 authors.
Funding
Abstract
The primary objective of this study was to determine the impact of whole-body periodic acceleration (WBPA) as a countermeasure on preventing bone loss caused by hindlimb unloading. 48 male Sprague Dawley rats were randomized into four groups: (1) control group (C, n = 12), (2) hindlimb unloading group (HU, n = 12), (3) hindlimb unloading + WBPA group (HU + WBPA, n = 12), and (4) hindlimb unloading + flat rest group (HU + FR, n = 12). WBPA consisted of 1 h of acceleration stimulation, administered once daily using a specially designed training device. After 28 days of hindlimb unloading, Micro-CT analyses showed significant decreases in bone mineral density (BMD, p < 0.0001), bone volume to tissue volume (BV/TV, p < 0.0001), trabecular thickness (Tb.Th, p < 0.0001) of femoral cancellous bone and cortical area (Ct.Ar, p < 0.0001) of femoral cortical bone. The application of WBPA for 1 h/day, significantly increased BMD (p < 0.05), BV/TV (p < 0.05) and Tb.Th (p < 0.0001) of femoral cancellous bone, relative to HU. Three-point bending test of HU femurs showed reduced maximum load (p < 0.0001), elastic load (p < 0.0001) and energy absorption (N.mm) (p < 0.0001). In comparison to HU, WBPA-treated bone showed increased maximum load (p < 0.0001), elastic load (p < 0.0001) and energy absorption (p < 0.001). In summary, this study demonstrates the potential of WBPA as an innovative solution to combat bone loss caused by long-term hindlimb unloading.
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Registered trials
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