Evidence map›Paper›PMID 41442803›Full record

ArticleCell calcium2026

Ablation of mitochondrial calcium uniporter alleviates cardiac dysfunction in type 1 diabetes.

Arpita Deb, Valeria Gomez, Yujia Cheng, Zhuoxin Li, Jinying Yang, Imtiaz Dowllah, Ngoc Nguyen, Oluwabori Adekanye, Ashley J Smuder, Zhiyong Cheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arpita DebDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Valeria GomezFood Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Yujia ChengFood Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Zhuoxin LiDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Jinying YangFood Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Imtiaz DowllahDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Ngoc NguyenFood Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Oluwabori AdekanyeDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Ashley J SmuderDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Zhiyong ChengFood Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Bin LiuDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA; Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA. Electronic address: binliu1@ufl.edu.

Funding

Doxorubicin cardiotoxicity and the protective effects of exerciseR01HL144858 · NHLBI · UNIVERSITY OF FLORIDA · PI SMUDER, ASHLEY · 2019 to 2023
$1.9M
Role of SR-mitochondria interplay in calcium-dependent arrhythmiasR01HL166169 · NHLBI · UNIVERSITY OF FLORIDA · PI Bin Liu · 2024 to 2026
$1.4M
Exploring the role of mitochondria in dysregulated calcium handling in diseased heartsR15HL154073 · NHLBI · MISSISSIPPI STATE UNIVERSITY · PI LIU, BIN · 2021 to 2021
$423k
NHLBI NIH HHS R01 HL144858NHLBI NIH HHS R01 HL166169NHLBI NIH HHS R15 HL154073
6 · The paper itself

Abstract

Calcium (Ca

Indexed as

Calcium ChannelsDiabetes Mellitus, Type 1Diabetic CardiomyopathiesAnimalsApoptosisArrhythmias, CardiacCalciumDiabetes Mellitus, ExperimentalMaleMiceMice, Inbred C57BLMice, KnockoutMitochondria, HeartMyocytes, CardiacReactive Oxygen SpeciesCalciumCalcium Channelsmitochondrial calcium uniporterReactive Oxygen SpeciesArrhythmiasCa(2+) handlingDiabetic cardiomyopathyMCUMetabolic heart diseaseRyR2 leak

Identifiers

PMID41442803
PMCPMC13541298

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.