Evidence map›Paper›PMID 41444415›Full record

ArticleCommunications biology2025

Neural mechanisms of the V2M-PrL pathway mediate blue light-induced spatial memory impairment.

Yuan Zhang, Guang'an Tong, Weipeng Wang, Yaoyang Xu, Wenbo Zhang, Xiangmin Chen, Xuejie Wang, Qi Xu, Caihong Han, Liecheng Wang and 2 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Marine drugs · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan Zhang *Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Guang'an Tong *Department of Neurology, The First Affiliated Hospital of Anhui Medical University North District, Anhui Medical University, Hefei, China.
Weipeng WangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Yaoyang XuDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Wenbo ZhangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Xiangmin ChenDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Xuejie WangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Qi XuDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Caihong HanDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Liecheng WangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.ORCID http://orcid.org/0000-0002-6422-6186
Shijun WengState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Pingping ZhangDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China. pingpingzhang@ahmu.edu.cn.ORCID http://orcid.org/0000-0001-7453-6973

Funding

Natural Science Foundation of Anhui Province (Anhui Provincial Natural Science Foundation) 1808085QH277
6 · The paper itself

Abstract

Blue light has been shown to impair spatial memory in mice. However, the underlying neural circuit mechanisms of this impairment remain elusive. Our study revealed that 600-lux blue light disrupted spatial memory retrieval in male mice through the secondary visual cortex (V2M) → the prelimbic cortex (PrL) neural pathway. Specifically, viral tracing and multichannel fiber optic recordings demonstrated that glutamatergic V2M neurons (V2M

Indexed as

LightMemory DisordersPrefrontal CortexSpatial MemoryVisual CortexAnimalsBlue LightGABAergic NeuronsMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsOptogenetics

Identifiers

PMID41444415
PMCPMC12783663

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.