Evidence map›Paper›PMID 41444421›Full record

ArticleCurrent microbiology2025

Proteomic Alterations and Antimicrobial Effects of Postbiotics from Probiotic Lactic Acid Bacteria and Yeast Against Multidrug-Resistant Salmonella Typhimurium.

Mahdi Asghari Ozma, Seyyed Reza Moaddab, Mohammad Asgharzadeh, Fadhil S Kamounah, Amin Abbasi, Niloofar Fallahi Alileh, Hossein Samadi Kafil

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Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahdi Asghari OzmaDepartment of Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. asghariozma@gmail.com.ORCID http://orcid.org/0000-0002-4918-8820
Seyyed Reza MoaddabDepartment of Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad AsgharzadehBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Fadhil S KamounahDepartment of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen, DK- 2100, Denmark.
Amin AbbasiDepartment of Food Science and Technology, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Niloofar Fallahi AlilehDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hossein Samadi KafilDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study conducted presents the antimicrobial and antibiofilm properties of postbiotics obtained from Bifidobacterium bifidum, Lactiplantibacillus plantarum, and Saccharomyces cerevisiae against multidrug-resistant Salmonella enterica serotype Typhimurium. Integrated microbiological and proteomic approaches proved that all postbiotics inhibited bacterial growth as well as biofilm formation with high biocompatibility to mammalian cells. Transcriptional and proteomic analyses indicated that exposure to postbiotics modulated major virulence-associated genes and proteins related to motility, adhesion, and stress adaptation. These molecular changes allow the assumption that postbiotics are able to attenuate pathogenicity through multifactorial mechanisms rather than direct bactericidal effects. In summary, this study results in an expression of interest in probiotic-derived postbiotics as safe and stable non-antibiotic agents for the control of multidrug-resistant pathogens in biofilm-related infections.

Indexed as

Anti-Bacterial AgentsBifidobacterium bifidumProbioticsProteomeSaccharomyces cerevisiaeSalmonella typhimuriumBiofilmsDrug Resistance, Multiple, BacterialHumansProteomicsAnti-Bacterial AgentsProteome

Identifiers

PMID41444421

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.