Evidence map›Paper›PMID 41444477›Full record

Trial reportNature communications2025

Zishen Yutai Pill increased live births in advanced maternal age women: a randomized clinical trial.

Yu Li, Fei Gong, Xiaohong Wang, Linli Hu, Hong Li, Yichun Guan, Hong Ye, Li Fan, Haiyan Bai, Ze Wang and 4 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03703700 (The Application of Zishen Yutai Pill in Aged Women Undergoing in Vitro Fertilization-embryo Transfer), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03703700 nacompletednot on this map

The Application of Zishen Yutai Pill in Aged Women Undergoing in Vitro Fertilization-embryo Transfer: a Multi-center Double-blind Randomized Controlled Trial

TypeinterventionalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2019 to 2024Enrolled1,467ConditionsInfertility, FemaleArmsZishen Yutai Pill, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yu LiCenter for Reproductive Medicine, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Fei GongCenter of Reproductive Medicine, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China.
Xiaohong WangReproductive Medical Center, Tangdu Hospital, the Fourth Military Medical University, Xi'An, Shanxi, China.
Linli HuCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Hong LiReproductive Genetic Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Yichun GuanReproductive Medicine Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID http://orcid.org/0000-0002-6255-2551
Hong YeCenter for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Li FanDepartment of Reproductive Medicine, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China.
Haiyan BaiAssisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'An, Shanxi, China.
Ze WangCenter for Reproductive Medicine, Hospital for Reproduction Medicine Affiliated to Shandong University, Jinan, Shandong, China.
Wei HuangDivision of Reproductive Medical Center, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
Xiaoling MaReproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Dongzi YangCenter for Reproductive Medicine, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. yangdz@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-9587-1535
Heping ZhangDepartment of Biostatistics, Yale University School of Public Health, New Haven, Connecticut, USA. heping.zhang@yale.edu.ORCID http://orcid.org/0000-0002-0688-4076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced maternal age (AMA, ≥35 years) women undergoing assisted reproductive technology (ART) face reduced live birth rates (LBR) and remain a major clinical challenge. In a large randomized trial, Zishen Yutai Pill (ZYP) improved LBR in the general population, and a subsequent post hoc analysis suggested efficacy in AMA women, though it was underpowered to draw firm conclusions. To address the issue, we conducted a multicenter, prospective, double-blind, placebo-controlled, randomized trial (NCT03703700) to evaluate whether ZYP increases LBR in AMA women. Women aged 35-42 years with BMI < 28 kg/m

Indexed as

Drugs, Chinese HerbalLive BirthMaternal AgeAdultAdvanced Maternal AgeBirth RateChinaDouble-Blind MethodEmbryo TransferFemaleHumansPregnancyPregnancy RateProspective StudiesDrugs, Chinese Herbal

Identifiers

PMID41444477
PMCPMC12848059

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.