Evidence map›Paper›PMID 41444632›Full record

ArticleJournal of translational medicine2025

Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren's syndrome and identifies PS(36:1) as a potential therapeutic target.

Yanxiong Shao, Ningning Cao, Fei Qian, Diqing Wu, Yuting Yang, Yichao Xia, Zongze Shen, Lijuan Zhu, Jiajia Li, Yeping Lu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yanxiong Shao *Department of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ningning Cao *Department of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Fei Qian *Department of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Diqing WuDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuting YangDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yichao XiaDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Zongze ShenDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Lijuan ZhuDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiajia LiDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yeping LuDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Chaoran LiDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ying SongDepartment of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Tianyu XiaoDepartment of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Tianlin LuDepartment of Rheumatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Jingwen YangDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Junqin LuDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhenrong HuDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Xudong WangDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yubo XuDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. 1247845178@qq.com.
Jie ZhangDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. 371616870@qq.com.

Funding

Shanghai East Hospital Scientific Research Start-Up Fund for the Introduction of Talent DFRC2021006Shanghai East Hospital Youth Scientific Research Cultivation Fund DFPY2022005
6 · The paper itself

Abstract

backgroundSjögren syndrome (SS) is a common autoimmune disease characterized by lymphocytic infiltration. Describing the transcriptional and metabolic features of the disease from a spatial perspective can enhance our understanding of the disease pathogenesis and treatment;

methodsWe collected eight human labial samples, including four labial gland samples from patients with SS and from four healthy controls. We integrated single-cell RNA sequencing, spatial transcriptomics, and spatial metabolomics techniques to generate SS-associated spatial gene expression maps and spatial metabolite profiles at a single-cell resolution. We also analyzed the characteristic metabolic and genetic changes of SS samples and infiltrated CD4

resultsComprehensive data from spatial multi-omics identified the cell types and distributions within the immune microenvironment of salivary glands in SS. CCL19 was significantly increased in lymphocyte infiltration, while IGHG4 was elevated in glandular area. Linoleic acid metabolism undergoes reprogramming in SS, with alterations in lecithin, linoleic acid, 13(S)-hydroxyoctadecadienoic acid and dihomo-γ-linolenate. Furthermore, PS (36:1) was found to be abnormally enriched in lymphocyte focus, which may be related to the abnormal expression of CD74 and HLA-DRA. Also, CXCL13 corresponded to areas resembling high levels of PS(36:1) in infiltrated CD4

conclusionsThe multi-omics analysis conducted in this study enhances our understanding of the key regulatory mechanisms driving the pathogenesis of SS and offers novel insights for its precision therapy. Furthermore, PS(36:1) emerged as a potential therapeutic target for future SS research and treatment.

Indexed as

Gene Expression ProfilingMetabolomicsMolecular Targeted TherapySjogren's SyndromeAdultAnimalsCD4-Positive T-LymphocytesFemaleHumansMaleMetabolomeMiceMice, Inbred NODMiddle AgedMultiomicsSalivary GlandsCD4+ T cellsLinoleic acid metabolismPS (36:1)Sjogren syndromeSpatial multi-omics

Identifiers

PMID41444632
PMCPMC12729014

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.