Evidence map›Paper›PMID 41444843›Full record

ArticleAnnals of surgical oncology2026

Depth of Tumor Invasion (T-Stage) is Not Associated with Survival or Recurrence Rates in Patients Undergoing Surgery for pT1 and pT2 Colon Cancer.

Julia Hanevelt, Eva Rademaker, Bobby Zamaray, Richard M Brohet, Leon M G Moons, Frank P Vleggaar, Bart C T van de Laar, Esther C J Consten, Pieter J Tanis, Wouter H de Vos Tot Nederveen Cappel and 3 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julia HaneveltDepartment of Gastroenterology and Hepatology, Isala, Zwolle, The Netherlands. j.hanevelt@isala.nl.ORCID http://orcid.org/0000-0001-7418-9190
Eva RademakerDepartment of Surgery, Isala, Zwolle, The Netherlands.
Bobby ZamarayDepartment of Surgery, Isala, Zwolle, The Netherlands.
Richard M BrohetDepartment of Epidemiology and Statistics, Isala, Zwolle, The Netherlands.
Leon M G MoonsDepartment of Gastroenterology and Hepatology, University Medical Centre Utrecht (UMCU), Utrecht, The Netherlands.
Frank P VleggaarDepartment of Gastroenterology and Hepatology, University Medical Centre Utrecht (UMCU), Utrecht, The Netherlands.
Bart C T van de LaarDepartment of Surgery, Meander Medisch Centrum, Amersfoort, The Netherlands.
Esther C J ConstenDepartment of Surgery, Meander Medisch Centrum, Amersfoort, The Netherlands.
Pieter J TanisDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Wouter H de Vos Tot Nederveen CappelDepartment of Gastroenterology and Hepatology, Isala, Zwolle, The Netherlands.
Henderik L van WestreenenDepartment of Surgery, Isala, Zwolle, The Netherlands.
Dutch Snapshot Research Group (DSRG)
Dutch Complex Colon Cancer Initiative (DCCCI)

Funding

KWF Kankerbestrijding call number 2021-1KWF Kankerbestrijding KWF-grant project 13209
6 · The paper itself

Abstract

backgroundOrgan preservation is gaining attention, yet primary treatment approaches differ substantially between pT1 and pT2 colon cancer (CC). This study evaluates whether tumor invasion depth affects survival outcomes in patients with pT1-2N0-2 colon cancer.

methodsIn this nationwide cohort study, patients undergoing surgery for pT1 or pT2 CC between 2014 and 2015 were identified from the Dutch Snapshot Research Group's SNAPSHOT complex colon cancer database. Five-year disease-free survival (DFS) and overall survival (OS) was analyzed using Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models.

resultsA total of 2312 patients were included (921 pT1 and 1391 pT2). Five-year DFS (83.5% vs. 83.2%, P = 0.79, adjusted HR [HR

conclusionsTumor invasion depth (pT1 or pT2) had no significant impact on DFS or OS following formal oncological resection. Furthermore, most distant metastases develop in pN0 patients, suggesting a minor influence of surgery on control of distant disease.

Indexed as

Colonic NeoplasmsNeoplasm Recurrence, LocalAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisSurvival RateColorectal cancerColorectal surgeryEarly-stage colon cancerLymph node metastasesOrgan preservationT1 colon cancerT1 CRCT2 colon cancer

Identifiers

PMID41444843

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.