Evidence mapPaperPMID 41444902Full record

ReviewJournal of nanobiotechnology2025

Emerging nanomedicine for liver diseases treatment.

Yawen Zhu, Dongxue Ge, Jinglin Wang, Hao Sun, Wei Li, Haozhen Ren

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yawen ZhuDivision of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Hepatobiliary Institute, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Dongxue GeDivision of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Hepatobiliary Institute, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Jinglin WangDivision of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Hepatobiliary Institute, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Hao SunDepartment of Emergency Medicine, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China. haosun_826@nju.edu.cn.
Wei LiDepartment of Neurosurgery, Nanjing Drum Tower Hospital, Clinical College of Jiangsu University, Nanjing, 210008, China. wei.li@nju.edu.cn.
Haozhen RenDivision of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Hepatobiliary Institute, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China. renhaozhen1984@163.com.

Funding

the National Natural Science Foundation of China 82270646
6 · The paper itself

Abstract

The liver is the largest parenchymal organ in the human body, crucial for overall health. However, hepatic diseases have become a global epidemic, causing significant burdens. While traditional therapies for liver diseases such as hepatic fibrosis, non-alcoholic fatty liver disease, and hepatocellular carcinoma have shown limited efficacy and significant side effects, the advent of nanotechnology has introduced novel and promising therapeutic strategies. Nanomedicine, with its excellent biocompatibility, surface modification capabilities, and high targeting ability, has the potential to revolutionize liver disease treatment. Here, we systematically review the latest advancements in nanomaterials for liver diseases, focusing on innovative nanocarriers such as exosomes, liposomes, microneedle technologies, biomimetic microfibers, and emerging platforms. We highlight critical gaps in current nanomedicine research, including biocompatibility and toxicity concerns, scalability and cost-effectiveness of production, and the need for personalized medicine and patient-specific nanotherapies. By addressing these challenges, nanotechnology can provide a multifunctional and powerful platform to significantly improve liver health and overcome existing limitations in clinical translation.

Indexed as

Liver DiseasesNanomedicineAnimalsDrug Delivery SystemsHumansLiposomesNanostructuresLiposomesBiomedical engineeringLiver diseaseNanomedicineTreatment outcome

Identifiers

PMID41444902
PMCPMC12729200

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.