Evidence map›Paper›PMID 41445691›Full record

ReviewImmunotherapy advances2025

Turning the tide: harnessing vaccines and viruses to fight cancer.

Callum Blee, Munitta Muthana, Greg Wells, Sarah Danson

Abstract readReview
In one paragraph

Review in Immunotherapy advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Callum BleeSheffield Ex-Vivo Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Munitta MuthanaSheffield Ex-Vivo Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Greg WellsSheffield Ex-Vivo Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Sarah DansonSheffield Ex-Vivo Group, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.ORCID https://orcid.org/0000-0002-3593-2890

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer vaccines and oncolytic viruses (OVs) represent promising immunotherapeutic strategies, harnessing adaptive and innate immune responses for targeted tumour eradication. Cancer vaccines aim to induce tumour-specific cytotoxic T lymphocytes (CTLs) through antigen presentation, while OVs mediate direct tumour lysis and stimulate immunogenic cell death, enhancing anti-tumour immunity. Despite keen interest, with over 350 clinical trials initiated since 2020, challenges persist in carrying the success seen in a pre-clinical setting to a clinical one. Advancements in preclinical modelling are essential for bridging the gap between

Indexed as

cancer vaccinesoncolytic virusespre-clinical models

Identifiers

PMID41445691
PMCPMC12723228

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.