Evidence map›Paper›PMID 41445838›Full record

ArticleBioactive materials2026

An intelligent nanoliposome alleviates disc degeneration and discogenic pain by inhibiting neurovascular ingrowth via a "Soil-conditioning, seed-modulating, and weeds-suppressing" strategy.

Fudong Li, Yangyang Shi, Junxia Liu, Yangzi Yang, Chen Yan, Xiaofei Sun, Zhiqiu Zhang, Bin Zhang, Qi Wang, Mu Du and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Fudong LiDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Yangyang ShiDepartment of Orthopedics & Spine Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230031, PR China.
Junxia LiuDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, PR China.
Yangzi YangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Chen YanDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Xiaofei SunDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Zhiqiu ZhangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Bin ZhangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Qi WangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Mu DuDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Ziran WangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Jingchuan SunDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Ximing XuDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Kaiqiang SunDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Jiuyi SunDepartment of Orthopedics, Naval Medical Center of PLA, Shanghai, 200052, PR China.
Yuan WangDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.
Jiangang ShiDepartment of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IVDD), a primary cause of debilitating low back pain, is driven by a vicious cycle involving a harsh microenvironment ("soil") and dysfunctional nucleus pulposus cells ("seeds"), which together promote pathological neurovascular ingrowth ("weeds") and pain. A therapeutic strategy that can simultaneously "condition the soil" and "modulate the seed" is therefore paramount. Thus, we engineered a biomimetic intelligent nanoliposome (NM-LP

Indexed as

angiogenesisHippo pathwayInnervationintervertebral disc degenerationNanoliposome

Identifiers

PMID41445838
PMCPMC12723136

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.