Evidence map›Paper›PMID 41446133›Full record

ArticlebioRxiv : the preprint server for biology2025

Melanoregulin Deficiency Affects Bone Maintenance and Lean Body Mass.

M L Musskopf, V De P Gonçalves, S Tuin, S W Wong, K Boesze-Battaglia, P A Miguez

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M L MusskopfDepartment of Restorative Sciences, Adams School of Dentistry, UNC-CH, Chapel Hill, NC, USA.
V De P GonçalvesDepartment of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
S TuinAdams School of Dentistry, UNC-CH, NC, USA.
S W WongDepartment of Periodontology, Endodontics and Dental Hygiene, Adams School of Dentistry, UNC-CH, Chapel Hill, NC, USA.
K Boesze-BattagliaDepartment of Basic & Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
P A MiguezDepartment of Periodontology, Endodontics and Dental Hygiene, Adams School of Dentistry, UNC-CH, Chapel Hill, NC, USA.ORCID 0000-0003-1255-3887

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
Lysosomal maturation during periodontal infectionsR01DE022465 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BOESZE-BATTAGLIA, KATHLEEN · 2012 to 2016
$2.0M
NIDCR NIH HHS R01 DE022465NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

Objectives: Studies documented the association of melanoregulin (MREG), a cargo-sorting protein, with its binding partner, the autophagic protein, microtubule-associated protein 1 light chain 3B (LC3B) in macrophages which could affect bone physiology due to the importance of autophagy in osteoclast function. Herein we propose to test the hypothesis that MREG modulates bone remodeling. Therefore, we analyzed the Methods: Mice femurs from wild type and MREG Results: There was a statistically significant difference in bone volume of 10-month old mice in wild type vs. MREG Conclusions: MREG deficiency seems to impact osteoclast numbers

Indexed as

autophagyBonefat metabolismmelanoregulinosteoclast

Identifiers

PMID41446133
PMCPMC12724551

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.