Evidence map›Paper›PMID 41446258›Full record

ArticlebioRxiv : the preprint server for biology2025

Mecp2 deficiency impairs microscale cortical network topology and dynamics in a Rett syndrome mouse model.

Alexander W E Dunn, Timothy P H Sit, Rachael C Feord, Asma Soltani, Yin Yuan, Richard Turner, Ines Loureiro, Stephen J Eglen, Ole Paulsen, Susanna B Mierau

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander W E DunnPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1504-499X
Timothy P H SitPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1149-0466
Rachael C FeordPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7801-8137
Asma SoltaniPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.
Yin YuanPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.
Richard TurnerPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.
Ines LoureiroPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.
Stephen J EglenApplied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8607-8025
Ole PaulsenPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2258-5455
Susanna B MierauPhysiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1220-6423

Funding

RESTORING CORTICAL NETWORK FUNCTION IN RETT SYNDROMEK02NS131521 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Susanna Mierau · 2024 to 2026
$773k
NINDS NIH HHS K02 NS131521Wellcome Trust
6 · The paper itself

Abstract

Rett syndrome is a debilitating neurodevelopmental disorder with cerebral processing impairments caused by

Indexed as

functional connectivitygraph theoryMecp2microelectrode arraymicroscale cortical networksnetwork topologyneuronal culturesRett syndromerich club topology

Identifiers

PMID41446258
PMCPMC12724707

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.