ArticleFrontiers in psychiatry2025
Quantitative computed tomography for assessing body composition in schizophrenia: a potential indicator of insulin resistance.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the relationship between the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index and organ body composition, and to evaluate the potential of quantitative computed tomography (QCT) parameters as biomarkers for indicating insulin resistance (IR) in schizophrenia. Materials and methods: A total of 924 patients with schizophrenia were enrolled and categorized into non-IR (HOMA-IR ≤ 2.5) and IR (HOMA-IR > 2.5) groups. Quantitative computed tomography (QCT) systematically measured parameters such as bone mineral density (BMD), hepatic fat fraction, and areas of subcutaneous adipose tissues (SAT) and visceral adipose tissues (VAT). Univariate and multivariate logistic regression analyses were performed to identify independent predictors of IR. The indicative performance of individual parameters and combined models-including a QCT parameters-only model and a model integrating QCT parameters with clinical covariates (gender, age, BMI)-was evaluated using receiver operating characteristic (ROC) curve analysis. Results: Patients in the IR group (n=332) demonstrated significantly elevated levels of all QCT parameters compared to the non-IR group (n=592): BMD (125.27 vs. 114.01 mg/cm³), liver fat (10.14% vs. 6.61%), SAT (138.55 vs. 82.20 cm²), and VAT (222.83 vs. 131.92 cm²) (all Conclusion: Visceral adipose tissue and liver fat content, as measured by QCT, are robust and independent indicator of insulin resistance in patients with schizophrenia. A model combining QCT parameters with basic clinical covariates offers the best predictive performance for identifying IR risk in this population, highlighting the critical role of ectopic fat deposition in metabolic dysregulation.
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