Reaching for the Stars in Atopic Dermatitis: Efficacy, Safety, Tolerability, Accessibility, and Remission/Remittive Effects (ESTAR).

Miranda An, Peter Lio

Abstract readEditorial

In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Miranda AnMs. An is with the University of California, Irvine School of Medicine in Irvine, California.

Peter LioDr. Lio is with the Department of Dermatology at Northwestern University Feinberg School of Medicine in Chicago, Illinois.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD), a chronic inflammatory skin condition affecting up to 20% of children and 7% of adults in the United States, significantly impacts quality of life through recurrent flares and persistent symptoms. This commentary introduces the ESTAR framework-Efficacy, Safety, Tolerability, Accessibility, and Remission/Remittive Effects-as a modernized tool for shared decision-making in AD management. By addressing critical factors such as efficacy (onset speed, depth, durability, and reliability), safety, tolerability, and remission potential, this framework can aid in evaluating emerging therapies with a patient-centered approach. The ESTAR framework emphasizes balancing immediate symptom relief with sustainable long-term disease control, offering tools such as a radar chart to help clinicians and patients navigate complex treatment options, improve adherence, and optimize outcomes in AD care.

Indexed as

accessibilityAtopic dermatitisdupilumabeczemaefficacyJanus kinase (JAK)remissionsafetytolerabilitytopical phosphodiesterase-4 (PDE-4) inhibitors

Identifiers

PMID41446716

PMCPMC12724998

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.