Evidence map›Paper›PMID 41446729›Full record

ArticleiScience2025

IFNγ signaling drives resistance to FLT3 inhibition in acute myeloid leukemia.

Abraheem Khouqeer, Justin Cartailler, Christina Kim, Kirsten M Dickerson, Chad R Potts, Anna E Gilbert, Robert S Welner, P Brent Ferrell

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abraheem KhouqeerProgram in Chemical and Physical Biology - Systems Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Justin CartaillerDepartment of Medicine, Division of Hematology/Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Christina KimDepartment of Medicine, Division of Hematology/Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Kirsten M DickersonDepartment of Medicine, Division of Hematology/Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Chad R PottsDepartment of Medicine, Division of Hematology/Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Anna E GilbertDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.
Robert S WelnerDivision of Hematology/Oncology and O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL, USA.
P Brent FerrellDepartment of Medicine, Division of Hematology/Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jason Daniel Buenrostro · 2017 to 2026
$24.6M
Role of bone marrow Tregs in maintaining stromal cell functionR01HL150078 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELNER, ROBERT S · 2020 to 2023
$1.5M
Delineating Drivers of Inflammation and Progression in Clonal HematopoiesisR56DK138826 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FERRELL, PAUL B · 2023 to 2023
$150k
BLRD VA I01 BX005991NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL150078NIDDK NIH HHS R56 DK138826
6 · The paper itself

Abstract

Resistance to targeted therapies remains a major challenge in acute myeloid leukemia (AML). In

Indexed as

cancercell biologyimmunologymicroenvironment

Identifiers

PMID41446729
PMCPMC12723130

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.