Comparative effects of hypoxic exercise training modalities on cardiometabolic health: A systematic review and network meta-analysis.

Jin Huang, Bin Chen, Li Ding, Jue Liu, Li Guo, Yinhang Cao, Olivier Girard

Abstract read

In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jin HuangSchool of Athletic Performance, Shanghai University of Sport, Shanghai, China.

Bin ChenDepartment of Public Physical Education, Fujian Agriculture and Forestry University, Fuzhou, China.

Li DingSchool of Athletic Performance, Shanghai University of Sport, Shanghai, China.

Jue LiuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Li GuoSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.

Yinhang CaoSchool of Athletic Performance, Shanghai University of Sport, Shanghai, China.

Olivier GirardSchool of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Western Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the benefits of various training modalities on cardiometabolic health and body composition are well-established under normoxic conditions, their efficacy in hypoxic environments remains unclear. We conducted a frequentist network meta-analysis (NMA) using random-effects models to evaluate the efficacy of hypoxic exercise modalities in individuals with excess body weight or obesity. Analysis revealed that combined hypoxic aerobic and resistance training is the most effective modality for improving body mass index, fat mass, and several cardiometabolic markers (e.g., low-density lipoprotein cholesterol, systolic blood pressure, and diastolic blood pressure). Hypoxic aerobic training is most beneficial for reducing triglycerides, while hypoxic high-intensity interval training is best for improving maximal oxygen consumption. This first NMA of hypoxic exercise establishes a hierarchy of modality-specific effects, enabling personalized prescription for individuals with excess body weight and obesity.

Indexed as

Health sciencesMedical science

Identifiers

PMID41446749

DOI10.1016/j.isci.2025.114194

PMCPMC12722976

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.