Evidence map›Paper›PMID 41447527›Full record

ArticleCell reports2026

Maternal diet shapes milk bile acids to regulate neonatal growth through TGR5.

Lufuno Phophi, Haley M Wilt, Zhengzheng Hu, Rishi Gadikota, Mallory Cadiz, Mikayla S Manzi, Freddie D Ortiz Martinez, Sarayu Vanga, Elizabeth G Chapman, Scott A Tibbetts and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lufuno PhophiDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Haley M WiltDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Zhengzheng HuDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Rishi GadikotaDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Mallory CadizDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Mikayla S ManziDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Freddie D Ortiz MartinezDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Sarayu VangaDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Elizabeth G ChapmanDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Scott A TibbettsDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Stephanie M KarstDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address: skarst@ufl.edu.

Funding

Elucidation of Pathogenic Mechanisms underlying Norovirus DiarrheaR01AI162970 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2021 to 2025
$3.0M
Regulation of enteric norovirus infection by host-derived and microbiota-transformed bile acidsR56AI141478 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2024 to 2024
$643k
NIAID NIH HHS R01 AI162970NIAID NIH HHS R56 AI141478
6 · The paper itself

Abstract

Maternal diet is critical in shaping neonatal metabolism and long-term health by governing breast milk composition. Although bile acids are present in breast milk, their functional role in infant development is not well understood. We identify enteromammary trafficking as the primary source of milk bile acids and show that this pool is modifiable by maternal diet. We also find that maternal bile acids regulate infant growth and levels of the growth-promoting hormone insulin-like growth factor 1 (IGF-1). Remarkably, maternal bile acid sequestration completely prevents excess weight gain in offspring nursed by dams on a high-fat diet. Supplementation with a bile acid or an agonist of the bile acid receptor TGR5 restores growth. Furthermore, TGR5-deficient pups phenocopy the maternal sequestration phenotype, supporting the model that maternal milk bile acids activate neonatal TGR5 to promote infant growth. Altogether, these findings reveal milk bile acids as active metabolic signals with potential for nutritional intervention in early-life programming.

Indexed as

Bile Acids and SaltsMilkReceptors, G-Protein-CoupledAnimalsAnimals, NewbornDiet, High-FatFemaleInsulin-Like Growth Factor IMaleMiceMice, Inbred C57BLBile Acids and SaltsGpbar1 protein, mouseInsulin-Like Growth Factor IReceptors, G-Protein-Coupledbile acidsbreastfeedingCP: metabolisminfant growthinfant metabolismmetabolic programmingmilk metabolitesobesityTGR5

Identifiers

PMID41447527
PMCPMC13335891

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.