Evidence map›Paper›PMID 41449302›Full record

ReviewDiscover oncology2025

Constructing an ultrasound-assisted organoid model for tumor management.

Tiantian Li, Xueying Wang, Miao Zhu, Sen Han, Dongyi Zhao, Vera Wong, Wangxing Huang, Zilin Li, Huajiao Zhao, Xiaoqin Qian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tiantian Li *Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Xueying Wang *Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Miao ZhuDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Sen HanDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Dongyi ZhaoDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Vera WongDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Wangxing HuangNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Zilin LiNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Huajiao ZhaoNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Xiaoqin QianNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China. yz_tyz1030@126.com.

Funding

National Natural Science Foundation of China [82471987]
6 · The paper itself

Abstract

Organoids, an emerging bioengineering approach, can replicate the structure and function of human organs in vitro, providing valuable tools for biomedical research. Patient-derived organoids (PDOs) retain the histological and genetic characteristics of the original tumor, playing a crucial role in precision oncology. Ultrasound-assisted technology, particularly multimodal ultrasound imaging, facilitates the establishment of PDOs for inoperable or rare tumors by enabling precise tumor localization, minimally invasive tissue sampling, and high-purity cell extraction.This review explores the application of multimodal ultrasound techniques in PDO development across various tumor types, highlighting their advantages in obtaining high-purity tumor cells, improving PDO culture success rates, and advancing personalized cancer treatment. Additionally, we discuss factors influencing PDO establishment, such as tumor type, sampling methods, and bioengineering advancements. By summarizing current progress and challenges, this review provides insights into optimizing ultrasound-assisted PDO construction for clinical and research applications.

Indexed as

Drug screeningIndividualized treatmentOrganoidsPatient managementUltrasound

Identifiers

PMID41449302
PMCPMC12847556

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.