Evidence map›Paper›PMID 41449346›Full record

ArticleBMC infectious diseases2025

Nationwide whole-genome sequencing reveals local transmission of Mycobacterium tuberculosis in Poland, 2003-2020.

Alina Minias, Lidia Fiedorowicz, Monika Kozińska, Anna Zabost, Jakub Lach, Marcin Słomka, Dominik Strapagiel, Jarosław Dziadek, Ewa Augustynowicz-Kopeć

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In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alina MiniasInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland. aminias@cbm.pan.pl.
Lidia FiedorowiczInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Monika KozińskaDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Anna ZabostDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Jakub LachCentre for Digital Biology and Biomedical Science - Biobank Lodz, University of Lodz, Lodz, Poland.
Marcin SłomkaCentre for Digital Biology and Biomedical Science - Biobank Lodz, University of Lodz, Lodz, Poland.
Dominik StrapagielCentre for Digital Biology and Biomedical Science - Biobank Lodz, University of Lodz, Lodz, Poland.
Jarosław DziadekInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Ewa Augustynowicz-KopećDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.

Funding

National Science Center of Poland 2019/35/B/NZ7/00942
6 · The paper itself

Abstract

backgroundTuberculosis (TB) remains highly prevalent in many countries and is a significant contributor to infectious disease mortality. Combating TB requires monitoring the global circulation of strains, and analyzing the prevalence of specific strains within populations. Currently, whole-genome sequencing (WGS) enables the precise tracking of TB transmission. Here, we utilized spoligotyping combined with whole-genome sequencing (WGS) to identify cases of M. tuberculosis transmission in Poland. Our study aimed to identify M. tuberculosis clones transmitting in Poland before the beginning of the war in Ukraine and the influx of refugees.

methodsWe used spoligotyping data to identify M. tuberculosis isolates that were possibly transmitted. We used WGS to confirm transmission, and to identify transmission chains.

resultsA total of 163 isolates were successfully sequenced with high-quality genomic data. Two significant clusters were identified: a pan-susceptible Euro-American lineage cluster (WGS-Cluster 3, n = 32, 19.6%) associated with patients experiencing homelessness and centered in Bydgoszcz (2006-2014); and a multidrug-resistant Beijing lineage cluster (WGS-Cluster 13, n = 32, 19.6%) emerging between 2016 and 2020 across five cities.

conclusionM. tuberculosis transmission should be monitored with routine WGS for better TB control in Poland.

Indexed as

Mycobacterium tuberculosisTuberculosisWhole Genome SequencingAdolescentAdultFemaleGenome, BacterialGenotypeHumansMaleMiddle AgedPolandYoung AdultDrug resistanceGenomic epidemiologyMycobacterium tuberculosisPolandTransmissionWhole genome sequencing

Identifiers

PMID41449346
PMCPMC12849491

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.