ArticleMaterials today. Bio2025
Mitochondrial biogenesis modulation by silicon-stimulated mesenchymal stem cells-derived extracellular vesicles drives angio- and lymphangiogenesis in chronic wound healing.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A tree-inspired liquid-managing scaffold with radial-axial continuity for wound exudate management.Materials today. Bio · 2026Article
- 3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration.Journal of nanobiotechnology · 2026Article
- Hydrogel-extracellular vesicle engineering delivery system: a promising therapeutic strategy for wound healing.Journal of nanobiotechnology · 2026Review
- Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury.Journal of nanobiotechnology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Diabetic wounds are characterized by chronic inflammation, reduced angiogenesis, and insufficient collagen deposition, leading to impaired healing. Extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSC) offer a promising cell-free therapeutic strategy; however, their efficacy and immunomodulation can be enhanced through bioactivation. In this study, we incorporated calcium silicate-stimulated ADSC-derived EVs (CSEVs) into collagen hydrogels to create a sustained-release system to promote diabetic wound healing. CSEVs exhibit enhanced protein content, surface marker expression, and bioactive cargo enriched with proangiogenic and anti-inflammatory factors. In addition, the suppression of proinflammatory signaling, polarization of M2 macrophages, stimulation of angiogenesis and lymphangiogenesis, and activation of mitochondrial function in dermal fibroblasts were among the many effects of CSEVs on the wound microenvironment. Moreover, miR-31 in CSEVs demonstrated an important factor in promoting difficult wound repair. These results highlight the potential of collagen scaffolds incorporated with CSEVs as strong acellular substrates for improving wound healing in diabetic environments. CSEVs and miRNA-mediated cues work together to overcome regeneration constraints of chronic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.