ReviewCureus2025
Non-invasive Diagnostics in the Focus: The Importance of Salivary Biomarkers in Detecting Oral Cancer.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Diagnostic accuracy of HPV DNA in oral gargle and rinse samples for Head and neck squamous cell carcinoma: A systematic review and meta-analysis.The Japanese dental science review · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral squamous cell carcinoma (OSCC) is a global health challenge, often diagnosed at advanced stages due to the invasiveness and limited accessibility of current methods like tissue biopsies. Salivary biomarkers have emerged as a transformative alternative, offering a non-invasive, cost-effective, and patient-friendly approach for early detection, prognosis, and treatment monitoring. This review highlights the mechanistic roles of salivary biomolecules, including microRNAs (miRNAs) (e.g., miR-31, miR-200a), proteins (interleukin-8 (IL-8), matrix metalloproteinase-9 (MMP-9)), circulating tumor DNA (ctDNA), and metabolites, in OSCC pathogenesis. We discuss advancements in salivaomics (genomics, proteomics, metabolomics) and technologies (biosensors, AI-driven multi-marker panels) that enhance diagnostic accuracy. Published data from validation studies indicate that several salivary biomarkers demonstrate strong diagnostic potential for OSCC detection. Despite ongoing advances, significant challenges such as biomarker variability, lack of standardized collection protocols, and the need for robust clinical validation currently limit the widespread adoption of salivary diagnostics in OSCC. Future research is focusing on integrated multi-omics strategies, the development of wearable real-time monitoring devices, and establishing regulatory frameworks to better facilitate clinical implementation. Addressing these issues may improve the reliability and accessibility of saliva-based diagnostics for OSCC, particularly in low-resource and high-risk populations.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.