ReviewCureus2025
Impact of Periodontal Interventions on Glycemic Indices and Periodontal Status Among Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis and type 2 diabetes mellitus (T2DM) reinforce one another via chronic inflammation and dysglycemia; we performed a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-conformant systematic review and meta-analysis of 10 randomized/controlled trials to assess whether periodontal interventions - non-surgical periodontal therapy (NSPT) alone or with adjuncts - improve glycemic indices and periodontal status in adults with T2DM. Eligible studies reported pre-/post-intervention hemoglobin A1c (HbA1c), fasting glucose, and/or periodontal outcomes [probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), plaque]; data were pooled in RevMan 5.4 using random-effects models, with subgroup analyses contrasting NSPT alone versus NSPT plus systemic/topical adjuncts, and pooled effects summarized from forest plots and small-study effects assessed by the funnel plot (FP). Across the participants, NSPT consistently improved PD, CAL, and BOP versus minimal care and produced small but favorable changes in HbA1c and fasting glucose; adjuncts such as hyaluronic acid or short-course antibiotics offered context-dependent, modest gains, with similar efficacy between antibiotic regimens. Some studies showed improved oxidative stress balance and diabetes-related quality of life despite minimal between-group HbA1c differences, and a large community program enhanced fasting plasma glucose (FPG)/HbA1c control and oral symptoms. Forest plots favored intervention for periodontal and (modestly) metabolic outcomes, with expected heterogeneity and no major funnel-plot asymmetry. Overall, periodontal interventions - particularly NSPT with standardized oral-hygiene instruction - reliably improve periodontal health and are associated with directionally favorable glycemic effects at three to six months; selective use of adjuncts and integrated self-management approaches may add benefit, and longer, larger trials are needed to define HbA1c durability and optimize adjunct selection and maintenance schedules.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.