SynthesisFrontiers in endocrinology2025
The effect of non-pharmacological interventions on bone health among patients with low bone mass: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Current Role of Physiotherapy in Systemic Light-Chain (AL) Amyloidosis and Multiple Myeloma.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective: Low bone mass represents a critical period for "watchful waiting" interventions to prevent osteoporosis. This systematic review provides a comprehensive overview of non-pharmacological interventions for patients with low bone mass. Methods: We included randomized controlled trials (RCTs) investigating the efficacy of non-pharmacological interventions for improving bone health outcomes in participants with low bone mass. Publications were collected from three databases. A meta-analysis was performed for outcomes reported in three or more articles, with changes in outcomes expressed as mean differences (MD) or standardized mean differences (SMD) with 95% confidence intervals (CIs). Results: A total of 26 eligible articles were included. Exercise interventions increased serum osteocalcin levels (SMD = 1.26, 95% CI: 0.22-2.31) compared to the control group. Narrative synthesis of studies showed a protective effect of exercise on lumbar spine and femoral neck BMD. For nutrition interventions, polyphenol extracts showed efficacy in improving lumbar spine BMD. The results of collagen supplements were inconsistent, and the effects of micronutrients were limited. Conclusion: In conclusion, more evidence from RCTs, particularly those investigating comprehensive lifestyle interventions and tailored prevention for moderate and severe low bone mass, especially among older men, is necessary.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.