ArticleFrontiers in psychiatry2025
Pre-pandemic brain structure and COVID-19 fear: insights into posttraumatic stress and general distress.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Various brain regions are implicated in fear responses to specific stimuli. While prior research has explored neural connectivity related to fear during COVID-19, gaps remain regarding the specific role of pre-pandemic brain structure in COVID-19-related fear and its impact on long-term psychological problems. This prospective longitudinal study aimed to explore the neural structural basis of individual differences in fear of COVID-19 during the peak of the COVID-19 outbreak in Chinese communities, as well as the neurobehavioral mechanisms by which this fear increased individual PTSD symptoms and general distress one year later. Methods: Preceding the COVID-19 outbreak, 115 university students from Chengdu, China, were recruited and underwent 3.0T magnetic resonance imaging scans to collect brain structural data. During the peak of the COVID-19 community outbreak, participants' fear was assessed using the Fear of COVID-19 Scale. One year later, long-term post-traumatic stress disorder (PTSD) symptoms and general distress were measured. Associations between Pre-Pandemic Brain Structure, COVID-19 Fear, Posttraumatic Stress and General Distress were examined using Structural equation model. Results: Whole-brain multiple regression analysis identified that baseline gray matter volume (GMV) in the left (r=0.42, p<0.001) and right insulae (r=0.39, p<0.001) was positively associated with the fear of COVID-19, after adjusting for sex, age, and total GMV. Mediation analysis revealed that this fear mediated the impact of bilateral insular GMV on PTSD symptoms and general distress one year later. Conclusions: The baseline bilateral insular GMV played a pivotal role in driving the level of fear during the peak of community outbreaks of COVID-19. Additionally, fear served as a crucial mediating factor influencing the association between insular and future psychological problems. These findings could aid in identifying vulnerable populations susceptible to fear during infectious disease outbreaks like COVID-19 and provide insights into identifying target areas for mental health interventions at different stages of future outbreaks.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.