SynthesisFrontiers in psychiatry2025
Exploring the bidirectional relationship between depressive disorder and dyslipidemia: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- External factors show reproducible local symptom-biomarker associations in middle-aged and older adults with heart disease.Frontiers in psychiatry · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore the bidirectional association between dyslipidemia and depression, and the potential predictive role of lipid level changes for depression onset. Methods: A systematic search of the Cochrane Library, Web of Science, Embase, and PubMed databases was conducted to identify cohort studies on blood lipids and 5-hydroxytryptamine (5-HT) parameters related to depression, from database inception to May 2024. Data were analyzed using Stata 14.0 software. Results: Seven studies were included in the analysis. Serum high-density lipoprotein (HDL) and triglyceride levels are significantly associated with an increased risk of depression (OR = 1.28, 95% CI: 1.07 - 1.53; OR = 1.41, 95% CI: 1.20 - 1.66, Conclusion: Based on the present findings, changes in serum HDL and triglyceride levels are significantly linked to depression incidence. Monitoring these two lipid parameters may aid in early identification of at-risk individuals and enhance the prognosis and quality of life for depressed patients through timely interventions. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024542833.
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