ReviewFrontiers in synaptic neuroscience2025
Synaptic transmission in supragranular layers of the human cortex - comparative review of structure, function, and plasticity.
Review in Frontiers in synaptic neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex.Pflugers Archiv : European journal of physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapses are the highly specialized connection sites between neurons enabling the establishment of complex neuronal networks. As highly plastic structures, synapses collocate both the transmission and storage of information, which is an essential prerequisite for learning and memory. Since synaptic deficits are associated with degenerative and neuropsychiatric diseases, it is essential to understand the mechanisms of synaptic plasticity. Throughout evolution, the human brain has developed distinct characteristics, such as supragranular expansion and enhanced long-range connectivity, suggesting an evolutionary specialization of synapses. Recent collaborative research, employing slice preparations obtained from neurosurgical resections of the human neocortex, has significantly advanced our understanding of the unique structural and functional properties of the human neocortex. This review investigates findings derived from diverse experimental methodologies, highlighting specific synaptic features. Focusing on synapses in supragranular layers, we discuss the distinctive synaptic structure, function, and mechanisms of plasticity that contribute to the unique circuitry of the adult human brain. Additionally, we outline emerging directions of research aimed at further elucidating the functionality of human cortical networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.