ReviewLife medicine2025
Peripheral organ crosstalk in the regulation of ovarian endocrine function and reproductive homeostasis.
Review in Life medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Data-driven endocrine-metabolic phenotypes in young women with polycystic ovary syndrome and associations with cardiometabolic risk markers.Journal of endocrinological investigation · 2026Article
- Algae-Derived Bioactives Reprogram the Gut-SIRT1-Kisspeptin Axis in Polycystic Ovary Syndrome.Marine drugs · 2026Review
- Decoding the gut-adipose-ovary axis in polycystic ovary syndrome: from metabolic dysregulation to oncological risk modulation.Frontiers in microbiology · 2026Review
- Integrative Network View of PCOS: Organ Crosstalk Driven by the Hyperandrogenemia-Insulin Resistance-Inflammation Triad.Journal of multidisciplinary healthcare · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian function is increasingly recognized as a systemic process influenced by cross-organ communication, yet knowledge regarding the underlying mechanisms remains fragmented. In addition to the ovary, multiple organs, including the hypothalamus, adipose tissue, gut, liver, thyroid, adrenal gland, and heart, converge to regulate ovarian function. These interactions span endocrine signals (e.g. insulin hormones), immune mediators (e.g. cytokines), and metabolic cues (e.g. adipokines), collectively impacting folliculogenesis, steroidogenesis, and ovulation. Importantly, these interactions suggest novel therapeutic targets to mitigate ovarian dysfunction. However, causal relationships and organ-specific contributions require further mechanistic exploration. This synthesis underscores the necessity of a multisystem perspective in both the research and clinical management of ovarian disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.