ArticleFrontiers in microbiology2025
Naringin as a non-antibiotic agent for multi-species oral biofilm control:
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Dental caries is driven by dysbiosis of oral biofilms. Conventional antibiotics easily disrupt oral commensal balance, creating an urgent need for natural, non-antibiotic agents that can target cariogenic biofilms without causing ecological collapse. Methods: The antimicrobial and antibiofilm efficacy of Naringin was evaluated Results: Naringin exhibited potent, concentration-dependent antimicrobial activity. MICs were 1.00 mg/mL for Discussion: Naringin, a natural non-antibiotic agent, effectively inhibits the "adhesion-biofilm-acid-EPS" cascade of multi-species cariogenic biofilms. Its selective efficacy against pathogens and favorable
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Registered trials
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