Evidence map›Paper›PMID 41450990›Full record

ArticlePakistan journal of medical sciences2025

Serum Aquaporin-1 and 3 Levels in Term Newborns.

Abdurrahman Avar Ozdemir, Gokhan Buyukkale, Ismail Dag

Abstract read
In one paragraph

Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abdurrahman Avar OzdemirAbdurrahman Avar Ozdemir, Department of Pediatrics, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkiye.
Gokhan BuyukkaleGokhan Buyukkale, Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkiye.
Ismail DagIsmail Dag, Department of Biochemistry, Eyupsultan Hospital, Istanbul, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the serum concentrations of Aquaporin 1-3, which are thought to be critical modulators of water transfer, and risk factors affecting them in neonates. Methodology: This prospective study was conducted in term neonates in a research hospital, from October 2023 to October 2024. Demographic data of infants and mothers were collected and high risk neonates were excluded. The neonates were divided into three groups based on birth weight percentiles as small for gestational age, appropriate for gestational age, and large for gestational age. Umbilical cord blood samples were obtained by umbilical artery puncture and blood gases, hemoglobin, Na, K, Cl, glucose, insulin, Aquaporin 1-3 were measured. The relationship between Aquaporin levels and risk factors was analyzed. Results: A total of 85 healthy term neonates were included in our study. The mean gestational age and birth weight of infants were found as 38.2 ± 1.1 weeks and 3245 ± 749 g. The mean Aquaporin 1-3 levels for all infants were found as 11.1 ± 5.6 and 22.8 ± 11.6 ng/ml, respectively. There was a strong correlation between Aquaporin 1-3 levels (r = 0.769). No significant difference was found in Aquaporin levels in terms of birth weights, but Aquaporin 1 levels of infants born by cesarean section were significantly higher than those born vaginally (p = 0.02). Conclusions: In this study, we determined serum Aquaporin 1-3 levels in term neonates and found that serum levels increased in cesarean-born infants, especially Aquaporin 1. These results provide preliminary reference values for serum Aquaporin 1-3 in term neonates and suggests a possible association with the mode of delivery.

Indexed as

Aquaporin 1Aquaporin 3AquaporinsNewborns

Identifiers

PMID41450990
PMCPMC12728692

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.