ReviewFrontiers in immunology2025
Mechanistic roles of neutrophil heterogeneity in tumour pathogenesis.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Immune response to DNA and RNA: structural insights, molecular mechanisms, and therapeutic targeting.Molecular biomedicine · 2026Review
- Circulating immune and biochemical markers predict tumor response to immunotherapy in advanced melanoma and lung cancer.Frontiers in immunology · 2026Article
- Tumor immune microenvironment in non-small cell lung cancer progression.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils are the body's primary responders to infection and injury, yet they also exert diverse effects within tumours through distinct subtypes and mechanisms of action. In light of persistent challenges in clinical oncology, including drug resistance, a research focus on neutrophil biology represents a promising frontier. This review examines neutrophil heterogeneity in cancer by exploring their developmental stages, tumour-specific mechanisms influencing progression, and established classification systems. It further highlights emerging neutrophil subpopulations identified across specific tumours and disease contexts, offering insights into their dual roles in pathogenesis. By integrating recent findings, this work provides a framework to guide drug development and clinical therapeutics in oncology and related pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.