Evidence map›Paper›PMID 41451297›Full record

ArticleChemical science2026

Wenjie Wang, Anjun Song, Fang Pu, Yanjie Zhang, Jinsong Ren, Xiaogang Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenjie WangLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China jren@ciac.ac.cn xqu@ciac.ac.cn.
Anjun SongLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China jren@ciac.ac.cn xqu@ciac.ac.cn.
Fang PuLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China jren@ciac.ac.cn xqu@ciac.ac.cn.ORCID https://orcid.org/0000-0001-6182-7966
Yanjie ZhangLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China jren@ciac.ac.cn xqu@ciac.ac.cn.
Jinsong RenLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China jren@ciac.ac.cn xqu@ciac.ac.cn.ORCID https://orcid.org/0000-0002-7506-627X
Xiaogang QuLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China jren@ciac.ac.cn xqu@ciac.ac.cn.ORCID https://orcid.org/0000-0003-2868-3205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cGAS-STING pathway represents an important target for amplifying immune responses in immunotherapy. This pathway is activatable by either endogenous or exogenous dsDNA. However, the effectiveness of these dsDNA sources is constrained by inadequate reactive oxygen species or limited sequence length. A unilateral source of endogenous or exogenous dsDNA may result in inadequate accumulation of the DNA pool, thereby restricting immune responses. Herein, a near-infrared light (NIR)-responsive nanoplatform has been developed by integration of bacterial outer membrane vesicles (OMVs) and high-entropy alloys (HEAs) into a hydrogen-bonded organic framework (HOF) to enhance intracellular DNA pools for activating the tumoral STING pathway and immunotherapy. The encapsulation of OMVs by HOFs dampens nonspecific activation of STING and systemic inflammation induced by lipopolysaccharides. Moreover, HEAs possess the capability to decompose HOFs, facilitating the intratumoral release of OMVs upon NIR exposure. The exogenous bacterial dsDNA present in OMVs, coupled with the endogenous dsDNA released by HEAs

Identifiers

PMID41451297
PMCPMC12728563

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.