Evidence map›Paper›PMID 41451763›Full record

ArticleImmunology and cell biology2026

Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans.

Christopher Menne, Naeimeh Tavakolinia, Louis Perriman, Wiebke Moskorz, Christine Cosmovici, Andreas Walker, Lara Olejnik, Katharina Raba, Mei Rm Du, Fernando J Rossello and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christopher MenneInstitute of Virology, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.ORCID https://orcid.org/0000-0003-2211-8766
Naeimeh TavakoliniaMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia.
Louis PerrimanMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia.
Wiebke MoskorzInstitute of Virology, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.
Christine CosmoviciInstitute of Virology, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.
Andreas WalkerInstitute of Virology, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.
Lara OlejnikInstitute of Virology, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.
Katharina RabaInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Mei Rm DuMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia.
Fernando J RosselloMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia.
Igor E KonstantinovMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia.
Stuart P BerzinsThe Fiona Elsey Cancer Research Institute, Ballarat, VIC, Australia.
Daniel G PellicciMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia.
Jörg TimmInstitute of Virology, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.

Funding

Deutsche Forschungsgemeinschaft DFG RTG 1949Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen 323-8.03-151826
6 · The paper itself

Abstract

Human invariant natural killer T cells (iNKT) play an important role in an orchestrated immune response; however, the heterogeneity of iNKT subsets is not yet fully understood. Here, we uncovered CD38 as a marker of iNKT differentiation, decoupling it from its role as a marker of activation by comparing the phenotype, cytokine profile and transcription factor expression of iNKT cell subsets in humans. Expression of CD38 on resting iNKT cells was restricted to cells that were low in well-described maturity markers such as CD161 and CCR5 and co-expressed markers associated with undifferentiated T cells (CD45RA, CCR7, CD62L). High abundance of CD38

Indexed as

ADP-ribosyl Cyclase 1Membrane GlycoproteinsNatural Killer T-CellsCell DifferentiationCytokinesHumansImmunophenotypingInfantLymphocyte ActivationThymus GlandADP-ribosyl Cyclase 1CD38 protein, humanCytokinesMembrane GlycoproteinsCD38flow cytometryhuman immunologyinvariant natural killer T cellslymphocyte differentiationNKT cells

Identifiers

PMID41451763
PMCPMC12872403

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.