ArticleAging cell2026
The Disrupted Bidirectional Regulation and Coupling of Resting-State Blood Pressure and Heartbeat in Hypertension.
Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Temporal Interference Stimulation Modulates Resting State Functional Connectivity of Motor Circuit in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Trial
- The Disrupted Bidirectional Regulation and Coupling of Resting-State Blood Pressure and Heartbeat in Hypertension.Aging cell · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The bidirectional non-linear communication between blood pressure (BP) and heartbeat is critical to cardiovascular homeostasis, which remains poorly understood, especially under hypertensive conditions. We implemented transfer entropy (TE), an information-theoretic measure of directional coupling, to characterize such bidirectional coupling between BP and heartbeat and its relationships to arterial stiffness and walking performance in older adults. A total of 493 older adults (201 normotensive (NTN), 168 controlled-hypertensive (controlled-HTN), and 124 uncontrolled-HTN) completed simultaneous recordings of resting-state beat-to-beat BP and R-R interval for ≥ 10 min. The TE from BP to RR (i.e., BP-RR) and from RR to BP (RR-BP) was quantified. Participants then completed the assessments of arterial stiffness (i.e., brachial-ankle pulse wave velocity, baPWV) and walking speed in single- and dual-task conditions. The validation using surrogate data confirmed the physiological significance of TE (p < 0.0001). Both BP-RR and RR-BP TE were significantly lower in controlled- and uncontrolled-HTN compared to NTN (p < 0.03). In NTN and control-HTN, higher BP-RR and/or RR-BP TEs were associated with slower walking speed (β = -0.25 to -0.16, p < 0.04). Higher BP-RR TE was associated with lower baPWV (β = -0.17 to -0.16, p < 0.04), while higher RR-BP TE was associated with greater baPWV (β = 0.17-0.21, p < 0.03). No such significant associations were observed within uncontrolled-HTN. The observations suggested that TE captures hypertension-related disruption of bidirectional BP-heartbeat information flow, reflecting impaired baroreflex feedback, exaggerated feedforward cardiac influence, and dampening with anti-hypertensive therapy. The distinct associations with vascular stiffness and walking performance suggest TE as a promising marker of cardiovascular integrity and functional reserve in aging.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.